Prognostic value of chest x-ray- and CT-defined large mediastinal adenopathy in high-risk pediatric Hodgkin lymphoma: A report from the Children's Oncology Group Study AHOD0831.

LMA according to MV  > 200 mL, MD  > 10 cm, and MD /TD > 1/3 is associated with poor prognosis in advanced-stage HL patients with SER. The normalized mediastinal diameter, MD /TD > 1/3 appears to be the strongest predictor of inferior RFS.