Persistent Exhausted T-Cell Immunity after Severe COVID-19: 6-Month Evaluation in a Prospective Observational Study.

Elena Vazquez-Alejo,Laura Tarancon-Diez,Maria de la Sierra Espinar-Buitrago,Miguel Genebat,Alba Calderón,Guillermo Pérez-Cabeza,Esmeralda Magro-Lopez,Manuel Leal,Mª Ángeles Muñoz-Fernández

Journal of clinical medicine（2023）

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摘要

The immunological activation in the SARS-CoV-2 group during hospitalization is reversed at the follow-up time point. However, the marked exhaustion pattern remains over time. This dysregulation could constitute a risk factor for reinfection and the development of other pathologies. Additionally, high SARS-CoV-2-specific T-cells response levels appear to be associated with infection severity.

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关键词

SARS-CoV-2, severe COVID-19, hospitalization, immune exhaustion profile, SARS-CoV-2-specific T-cell response, long-term evolution

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