Manufacturing innovation to drive down cell therapy costs.

Minsoo Khang, Smruthi Suryaprakash,Megan Kotrappa, Widya Mulyasasmita, Shana Topp,John Wu

Trends in biotechnology(2023)

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摘要
Chimeric antigen receptor T cells (CAR-T) have demonstrated their potential to revolutionize cancer treatment. However, manufacturing remains a challenge. Multiple manufacturing innovations [e.g., vector and gene engineering, process improvements, hardware innovation, digital innovation, and point-of-care (POC) manufacturing] have the potential to help realize the full potential of CAR-T therapies.
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关键词
CAR-T,autologous,manufacturing,cell therapy,cancer therapy,process development
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