Risk Factors for Primary Bone Cancer After Childhood Cancer: A PanCare Childhood and Adolescent Cancer Survivor Care and Follow-Up Studies Nested Case-Control Study.

Raoul C Reulen,David L Winter,Ibrahim Diallo,Cristina Veres,Damien Llanas,Rodrigue S Allodji,Francesca Bagnasco,Edit Bárdi,Elizabeth A M Feijen,Daniela Alessi,Miranda M Fidler-Benaoudia,Stine Høgsholt,Jop C Teepen,Helena Linge,Nadia Haddy,Julianne Byrne,Ghazi Debiche,Desiree Grabow,Thorgerdur Gudmundsdottir, Romain Fauchery,Wael Zrafi,Gisela Michel,Hilde Øfstaas,Peter Kaatsch,Giao Vu-Bezin,Helen Jenkinson,Melanie Kaiser,Roderick Skinner,Trevor Cole,Nicolas Waespe,Grit Sommer, Susanne Nordenfelt,Momcilo Jankovic,Tuomas Lähteenmäki Taalas,Milena M Maule,Helena J H van der Pal,Cécile M Ronckers,Flora E van Leeuwen,Judith L Kok,Monica Terenziani,Maria Winther Gunnes,Thomas Wiebe,Carlotta Sacerdote,Zsuzsanna Jakab,Riccardo Haupt,Päivi M Lähteenmäki,Lorna Zadravec Zaletel,Claudia E Kuehni,Jeanette Falck Winther,Leontien C M Kremer,Lars Hjorth,Florent de Vathaire,Michael M Hawkins

Journal of clinical oncology : official journal of the American Society of Clinical Oncology（2023）

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摘要

To our knowledge, we demonstrate-for the first time-that the risk of bone cancer is increased 5- to 10-fold after exposure of bone tissue to cumulative radiation doses of 1-9 Gy. Alkylating agents exceeding 10,000 mg/m increase the risk 7- to 8-fold, particularly following procarbazine, ifosfamide, and cyclophosphamide. These substantially elevated risks should be used to develop/update clinical follow-up guidelines and survivorship care plans.

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关键词

primary bone cancer,adolescent cancer survivor pancare,childhood cancer,pancare childhood,case-control

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