Towards an individualized management of pubertal induction in girls with hypogonadism: insight into the best replacement outcomes from a large multicentre registry.

Giulia Rodari,Silvia Federici,Tommaso Todisco,Graziamaria Ubertini,Alessandro Cattoni,Marta Pagano,Federico Giacchetti,Eriselda Profka,Valeria Citterio,Dario Messetti,Valentina Collini,Davide Soranna, Erika Carbone,Maura Arosio,Giovanna Mantovani,Luca Persani,Marco Cappa,Marco Bonomi,Claudia Giavoli

European journal of endocrinology（2023）

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摘要

Our results provide evidence that progestins, hampering further changes in uterine volume and breast development, should be introduced only in the presence of a concomitant adequate 17β-oestradiol dose and an appropriate clinical response.

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关键词

hypogonadism,pubertal induction,best replacement outcomes

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