Complementary roles of EP2 and EP4 receptors in malignant glioma.

Jiange Qiu,Qianqian Li, Junqi Li,Fengmei Zhou, Peng Sang,Zhongkun Xia,Wei Wang,Lin Wang,Ying Yu,Jianxiong Jiang

British journal of pharmacology（2023）

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摘要

The compensatory roles of EP2 and EP4 in GBM development and growth suggest that concurrently targeting these two Gα -coupled PGE receptors might represent a more effective strategy than inhibiting either EP2 or EP4 alone for GBM treatment.

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关键词

antagonist, COX, GBM, glioblastoma, PD-L1, prostaglandin, tumour inflammation, tumour microenvironment

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