Extracellular flux analysis in intact cardiac tissue slices - a novel tool to investigate cardiac substrate metabolism in mouse myocardium.

Katharina Bottermann,Andre Spychala,Asena Eliacik,Ehsan Amin,S Erfan Moussavi-Torshizi,Nikolaj Klöcker,Axel Gödecke,Andre Heinen

Acta physiologica (Oxford, England)（2023）

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摘要

In conclusion, we describe a novel method to analyze cardiac substrate metabolism in intact cardiac tissue slices by extracellular flux analysis. The proof-of-principle experiment demonstrated that this approach has a sensitivity allowing the investigation of pathophysiologically relevant disturbances in cardiac substrate metabolism.

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cardiac substrate metabolism,extracellular flux analysis,intact cardiac tissue slices—a

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