The interplay between N6-methyladenosine and precancerous liver disease: molecular functions and mechanisms

N6-methyladenosine(m 6 A) is one of the most abundant modifications of mammalian cellular RNAs. m 6 A regulates various biological functions in epitranscriptomic ways, including RNA stability, decay, splicing, translation and nuclear export. Recent studies have indicated the growing importance of m 6 A modification in precancerous disease, influencing viral replication, immune escape, and carcinogenesis. Here, we review the role of m 6 A modification in HBV/HCV infection, NAFLD and liver fibrosis, and its function in liver disease pathogenesis. Our review will provide a new sight for the innovative treatment strategy for precancerous liver disease.