Proteomic analysis of urinary extracellular vesicles highlights specific signatures for patients with primary aldosteronism.

Lorenzo Bertolone,Annalisa Castagna,Marcello Manfredi,Domenica De Santis,Francesca Ambrosani, Elisa Antinori,Paolo Mulatero,Elisa Danese,Emilio Marengo,Elettra Barberis,Mariangela Veneri,Nicola Martinelli,Simonetta Friso,Francesca Pizzolo,Oliviero Olivieri

Frontiers in endocrinology（2023）

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摘要

Through this proteomic approach, we identified uEVs molecular indicators that can improve PA characterization and help in the gain of insights of the pathophysiological features of this disease. In particular, PA was characterized by a reduction of AQP1 and AQP2 expression as compared with EH.

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关键词

urinary extracellular vesicles (UEVs), primary aldosteronism, essential hypertension, proteomics, aquaporin 1 (AQP1), aquaporin 2 (AQP2), alpha-1-acid glycoprotein (AGP1)

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