Protective role of cGAS in NASH is related to the maintenance of intestinal homeostasis.

Marcelle de Carvalho Ribeiro,Yeonhee Cho,Jeeval Mehta,Xiaojing Wang,Mrigya Babuta,Christopher Copeland,Hosni Hussein,Donna Catalano,Yanbo Wang,Gyongyi Szabo

Liver international : official journal of the International Association for the Study of the Liver（2023）

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摘要

Our findings indicate that cGAS or STING deficiency exacerbate liver damage, steatosis, and inflammation in HF-HC-HSD diet-induced NASH, which might be linked to the disruption of the gut barrier.

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cGAMP, cGAS, intestine, liver damage, non-alcoholic steatohepatitis

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