Chronic hyperglycemia reduces the expression of intercellular adhesion molecules and increases intercellular hyperpermeability in the periodontal epithelium.

Yuki Narukawa,Naoyuki Sugiyama,Jiro Miura,Rentaro Yamashita,Shotaro Tominaga,Yoshihiro Izumi,Takeshi Bamba,Yasushi Ishihama,Yoichiro Kashiwagi,Shinya Murakami

Journal of periodontal research（2023）

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摘要

High glucose-induced impairment of intercellular adhesion molecule expression in gingival epithelial cells was related to the intercellular permeability of gingival cells, representing a possible link to hyperglycemia-related AGE signaling, oxidative stress, and ERK1/2 activation.

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关键词

barrier function, gingival epithelium, hyperglycemia, intercellular adhesion molecules, permeability

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