Zn(II)-catalysed enantioselective addition of alcohols and tert -butyl hydroperoxide to isatin-derived N -Boc ketimines.
Chemical communications (Cambridge, England)(2023)
摘要
Using binaphthyl-proline-based chiral ligands, Zn(II)-catalysed addition of alcohols and -butyl hydroperoxide to isatin-derived -Boc ketimines provided the isatin-derived C3 ,-aminals in up to 99% yield and up to 99% ee. The reactions could be carried out under mild conditions and a gram-scale reaction could be realized without the loss of the yield and enantioselectivity.
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