The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage.

Xingfei Zhu,Wei Liu,Xiangcheng Tang,Yulin Chen,Xiangyu Ge,Qin Ke,Xingmiao Liang,Yuwen Gan,Yingfeng Zheng,Ming Zou,Mi Deng,Yizhi Liu, David Wan-Cheng Li,Lili Gong

Journal of neuroinflammation（2023）

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摘要

This study indicates targeted degradation of BET by dBET6 exerts neuroprotective effects by inhibiting cGAS-STING in reactive retinal macrophages/microglia, and is expected to become a new strategy for treatment of retinal degeneration.

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关键词

Retinal degeneration, BET, Neuroinflammation, PROTAC, cGAS-STING, Microglia/macrophage

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