Epigenetic Association Analyses and Risk Prediction of RLS.

Philip Harrer,Nazanin Mirza-Schreiber,Vanessa Mandel,Sigrun Roeber,Ambra Stefani, Shamsun Naher,Matias Wagner,Christian Gieger,Melanie Waldenberger,Annette Peters,Birgit Högl,Jochen Herms,Barbara Schormair,Chen Zhao,Juliane Winkelmann,Konrad Oexle

Movement disorders : official journal of the Movement Disorder Society（2023）

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摘要

DNA methylation supports the notion of altered neurodevelopment in RLS. Epigenetic risk scores are reliably associated with RLS but require even higher accuracy to be useful as biomarkers. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

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关键词

restless legs syndrome (RLS), epigenome-wide association studies (EWAS), methylation risk score, epigenetic age

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