Vesicular Glutamate Transporter Changes in the Cortical Default Mode Network During the Clinical and Pathological Progression of Alzheimer's Disease.

Zhiping Mi,Eric E Abrahamson, Angela Y Ryu,Michael Malek-Ahmadi,Julia K Kofler,Kenneth N Fish,Robert A Sweet,Victor L Villemagne,Julie A Schneider,Elliott J Mufson,Milos D Ikonomovic

Journal of Alzheimer's disease : JAD（2023）

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摘要

Frank loss of VGluT1 in advanced AD relative to NCI occurs in both DMN regions. In FC, an upregulation of VGluT1 protein content in remaining glutamatergic terminals may contribute to this region's plasticity response in AD.

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关键词

Alzheimer's disease, amyloid, glutamate, plasticity, synapse, vesicular glutamate transporter

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