CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation.

He Fang,Ana R Tronco,Giancarlo Bonora,Truong Nguyen,Jitendra Thakur,Joel B Berletch,Galina N Filippova,Steven Henikoff,Jay Shendure,William S Noble,Christine M Disteche,Xinxian Deng

bioRxiv : the preprint server for biology（2023）

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摘要

Our findings indicate that escape from XCI is modulated both by looping and insulation of chromatin via convergent arrays of CTCF binding sites and by compaction and epigenetic features of the surrounding heterochromatin.

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