Age-related increases in IGFBP2 increase melanoma cell invasion and lipid synthesis.

Gretchen M Alicea,Marie E Portuallo,Payal Patel,Mitchell E Fane,Alexis E Carey,David Speicher,Hsin-Yao Tang,Andrew V Kossenkov,Vito W Rebecca,Denis G Wirtz,Ashani T Weeraratna

bioRxiv : the preprint server for biology（2023）

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摘要

The aged microenvironment drives metastasis in melanoma cells. This study reports that IGFBP2 secretion by aged fibroblasts induces FASN in melanoma cells and drives metastasis. Neutralizing IGFBP2 decreases melanoma tumor growth and metastasis.

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