Modified Rotational Thromboelastometry Protocol Using Tissue Plasminogen Activator for Detection of Hypofibrinolysis and Hyperfibrinolysis.

Julie Brogaard Larsen,Christine Lodberg Hvas,Anne-Mette Hvas

Methods in molecular biology (Clifton, N.J.)（2023）

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摘要

Viscoelastic testing includes thromboelastography (TEG®) and thromboelastometry (ROTEM®) and is widely used in bleeding patients to detect hypocoagulability and guide transfusion therapy. However, the ability of standard viscoelastic tests to assess fibrinolytic capacity is limited. We here describe a modified ROTEM® protocol with addition of tissue plasminogen activator that can be used to identify hypofibrinolysis or hyperfibrinolysis.

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关键词

modified rotational thromboelastometry protocol,rotational thromboelastometry,hypofibrinolysis,hyperfibrinolysis,tissue plasminogen activator

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