Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection.

Ting-Ting Zhang,Qing-Qing Lei, Jie He,Xin Guan,Xin Zhang,Ying Huang,Zi-Yue Zhou,Rui-Xin Fan,Ting Wang,Chen-Xi Li,Jin-Yan Shang,Zhuo-Miao Lin,Wan-Li Peng, Li-Kai Xia, Yu-Ling He, Chuan-Ying Hong,Jing-Song Ou,Rui-Ping Pang,Xiao-Ping Fan,Hui Huang,Jia-Guo Zhou

Circulation（2023）

引用 1|浏览10

暂无评分

摘要

These findings unveil a critical role of Best3 in regulating smooth muscle cell phenotypic switch and aortic structural integrity through controlling MEKK2/3 degradation. Best3-MEKK2/3 signaling represents a novel therapeutic target for AD.

查看译文

关键词

trigger spontaneous aortic dissection,vascular smooth muscle

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要