Sacubitril/valsartan ameliorates renal tubulointerstitial injury through increasing renal plasma flow in a mouse model of type 2 diabetes with aldosterone excess.

Haruomi Nishio,Akira Ishii,Hiroyuki Yamada,Keita P Mori,Yukiko Kato,Shoko Ohno,Takaya Handa,Sayaka Sugioka,Takuya Ishimura,Akie Ikushima,Yui Inoue,Naoto Minamino,Masashi Mukoyama,Motoko Yanagita,Hideki Yokoi

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association（2023）

引用 0|浏览6

暂无评分

摘要

In a mouse model of type 2 diabetes with aldosterone excess, SAC/VAL increased RPF and GFR, and ameliorated tubulointerstitial fibrosis. Furthermore, RPF negatively correlated well with tubulointerstitial injury, suggesting that the beneficial effects of SAC/VAL could be through increased renal plasma flow with enhanced natriuretic peptide bioavailability.

查看译文

关键词

aldosterone, ARNI, diabetic kidney disease, GFR, RPF

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要