Different iPSC-derived neural stem cells shows various spectrums of spontaneous differentiation during long term cultivation.

Adelya Albertovna Galiakberova,Olga Igorevna Brovkina,Nikolay Vitalyevich Kondratyev, Alexander Sergeevich Artyuhov,Ekaterina Dmitrievna Momotyuk, Olga Nikolaevna Kulmukhametova,Alexey Aleksandrovich Lagunin, Boris Vladimirovich Shilov,Anton Dmitrievich Zadorozhny,Igor Sergeevitch Zakharov,Larisa Sergeevna Okorokova,Vera Evgenievna Golimbet,Erdem Bairovich Dashinimaev

Frontiers in molecular neuroscience（2023）

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摘要

Our results indicate that both internal (genetic and epigenetic) and external (conditions and duration of cultivation) factors influence the stability of NSCs. These results have important implications for the development of optimal NSCs culturing protocols and highlight the need to further investigate the factors influencing the stability of these cells .

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关键词

neural stem cells,spontaneous differentiation,ipsc-derived

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