Exploring the role of pyroptosis in shaping the tumor microenvironment of colorectal cancer by bulk and single-cell RNA sequencing.

Chengsheng Ding,Xiao Yang,Shuchun Li,Enkui Zhang,Xiaodong Fan,Ling Huang,Zirui He,Jing Sun,Junjun Ma,Lu Zang,Minhua Zheng

Cancer cell international（2023）

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摘要

Taken together, this study provides a comprehensive investigation of the role of pyroptosis in CRC at the bulk RNA sequencing (RNA-seq) and single-cell RNA sequencing (scRNA-seq) levels, advances our understanding of CRC characteristics, and guides more effective treatment regimens.

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关键词

Colorectal cancer, Pyroptosis, Tumor microenvironments, Immunotherapy, Single-cell analysis

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