Clinical characteristics of HFrEF patients with rare pathogenic variants in DCM-associated genes: a subgroup analysis of the PARADIGM-HF trial.

Ana Barat,Chien-Wei Chen,Natasha Patel-Murray,John J V McMurray,Milton Packer,Scott D Solomon,Akshay S Desai,Jean L Rouleau,Michael R Zile, Zenab Attari, Cong Zhang,Huilei Xu, Nicole Hartman, Claudia Hon,Margaret Healey,William Chutkow,Christopher J O'Donnell,Jaison Jacob,Marty Lefkowitz,Michael M Mendelson, Simon Wandel,Denise Yates, Claudio Gimpelewicz

European journal of heart failure（2023）

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摘要

Deleterious pLoF variants in genes with definitive/strong association to DCM were identified in ~5% of HFrEF patients from a PARADIGM-HF trial subset, who were younger, had lower EF and were less likely to have had an ischaemic aetiology. This article is protected by copyright. All rights reserved.

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