Moxifloxacin: Physical-chemical and Microbiological Analytical Methods in the Context of Green Analytical Chemistry.

Moxifloxacin (MOX) is a fourth-generation fluoroquinolone used in the form of tablets, infusion solutions and ophthalmic solutions. It does not have a physical-chemical or microbiological analytical method described in an official compendium. However, the literature shows some analysis methods for pharmaceuticals and biological matrices. In this context, the objective is to show the analytical methods present in the literature for the investigation of MOX by physical-chemical and microbiological techniques, as well as discussing them according to the requirements of current pharmaceutical analyses and green analytical chemistry. Among the physical-chemical methods present in the literature for MOX evaluation, 33% are HPLC, 21% are UV-Vis and 17% are capillary electrophoresis. On the other hand, among the microbiological methods, all of them are based on diffusion in agar. There is still scope in the literature to incorporate new and improved analytical methods for MOX evaluation, which adopt the concepts of green and sustainable analytical chemistry, either by using less (or not using) toxic organic solvents, reducing waste generation or even reducing the analysis time according to the intended objectives.