The Unique Genetic Mutation Characteristics Based on Large Panel Next-Generation Sequencing (NGS) Detection in Multiple Primary Lung Cancers (MPLC) Patients.

Zhu Liang, Guoxiong Zeng,Wang Wan,Biao Deng,Chunyuan Chen, Fasheng Li, Guanzhou Lin, Yuying Lin, Haitao Lin, Guixi Mo, Huilai Miao

Discovery medicine（2023）

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摘要

MPLC has a unique genetic mutation characteristic that differs from advanced patients and usually presents with low TMB. Comprehensive NGS helps to diagnose MPLC and guides the MPLC clinical treatment. is significantly enriched in IA nodules containing micro-papillary/solid components, suggesting that these MPLC patients may have a poor prognosis.

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关键词

multiple primary lung cancers,unique genetic mutation characteristics,next-generation

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