The battle against fungi- lessons in antifungal stewardship from COVID-19 times: a consensus statement on behalf of the International Society of Antimicrobial Chemotherapy, Alliance for the Prudent Use of Antibiotics, European Society of Clinical Microbiology and Infectious Diseases Study Group for Antimicrobial Stewardship, and European Society of Clinical Microbiology and Infectious Diseases Fungal Infection Study Group.

The COVID-19 pandemic has undoubtedly highlighted the detrimental effect of secondary pathogens in patients with a primary viral insult. In addition to superinfections with bacterial pathogens, invasive fungal infections were increasingly reported. While the diagnosis of pulmonary fungal infections has always been challenging, it became even more problematic in the setting of COVID-19 especially when it comes to the interpretation of the radiological findings and mycology test results in these patients. Moreover, the long duration of hospitalization in intensive care units coupled with underlying host factors such as multiple comorbidities including preexisting immunosuppression, the use of immunomodulatory agents and pulmonary compromise caused additional vulnerability to fungal infections in this patient population. In addition, the heavy workload during the COVID-19 outbreak, the redeployment of untrained staff, and sometimes the lack of gloves, gown and masks has made it more difficult for many healthcare workers to strictly adhere to infection control preventive measures. Taken together, these factors favored patient to patient spread of fungal infections such as those caused by Candida auris or environment to patient transmission such as nosocomial aspergillosis. Because fungal infections were associated with increased morbidity and mortality, empiric treatment was overly used and abused in COVID-19 infected patients, potentially contributing to increased resistance in fungal pathogens. In this paper, we aim to focus on essential elements of antifungal stewardship in COVID-19 for three fungal infections, namely COVID-19 associated candidemia (CAC), pulmonary aspergillosis (CAPA) and mucormycosis (CAM).