Neutrophils as key regulators of tumor immunity that restrict immune checkpoint blockade in liver cancer.

Mei Feng,Fangyanni Wang,Xinyu Liu,Tingting Hao,Ning Zhang,Mi Deng,Yisheng Pan,Ruirui Kong

Cancer biology & medicine（2023）

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摘要

Our data suggest that TANs may contribute to the resistance of liver cancer to ICB, and combining TAN depletion with T cell immunotherapy synergistically increases antitumor efficacy.

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关键词

Liver cancer, neutrophil, PD-1, CD8+T cell, exhaustion

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