Validation of a surgical model for posthepatectomy liver failure in rats.

Andrea Lund,Michelle Meier,Kasper Jarlhelt Andersen, Marie Ingemann Pedersen,Anders Riegels Knudsen,Jakob Kirkegård,Frank Viborg Mortensen

Animal models and experimental medicine（2023）

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摘要

Based on the GDS and liver-specific biochemistry, we concluded that the model of 90% PH seems to be a proper model for investigating PHLF in rats. As a high GDS is associated with increased mortality, the GDS appears to be valuable in detecting lethal outcomes caused by PHLF in rats.

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90% liver resection, general distress score, liver failure, post-hepatectomy liver failure, rats

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