Cisatracurium besylate rescues Mycobacterium Tuberculosis-infected macrophages from necroptosis and enhances the bactericidal effect of isoniazid.

Qian Wen, Jing Zhang, Zhanqing Zhang,Liru Chen,Honglin Liu,Zhenyu Han,Yaoxin Chen,Ke Wang,Jieyu Liu, Na Sai,Xinying Zhou,Chaoying Zhou,Shengfeng Hu,Li Ma

International immunopharmacology（2023）

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摘要

Cisatracurium besylate performs anti-Mycobacterium tuberculosis and anti-necroptotic roles, which potentiates its application to be an adjuvant drug for antituberculosis therapy to assist the battle against drug-resistant tuberculosis.

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关键词

Mycobacterium tuberculosis,Cisatracurium besylate,Necroptosis,RIPK3,MLKL

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