Optogenetic stimulation of the brainstem dorsal motor nucleus ameliorates acute pancreatitis.

Dane A Thompson,Tea Tsaava,Arvind Rishi,Sandeep Nadella,Lopa Mishra,David A Tuveson,Valentin A Pavlov,Michael Brines,Kevin J Tracey,Sangeeta S Chavan

Frontiers in immunology（2023）

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摘要

These results provide the first evidence that efferent vagus cholinergic neurons residing in the brainstem DMN can inhibit pancreatic inflammation and implicate the cholinergic anti-inflammatory pathway as a potential therapeutic target for acute pancreatitis.

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brainstem dorsal motor nucleus,optogenetic stimulation,acute pancreatitis

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