Circulating HPV DNA as a Biomarker for Pre-Invasive and Early Invasive Cervical Cancer: A Feasibility Study.

Stacey J Bryan,Jen Lee, Richard Gunu, Allison Jones,Adeola Olaitan,Adam N Rosenthal, Ros J Cutts,Isaac Garcia-Murillas,Nick Turner,Susan Lalondrelle,Shreerang A Bhide

Cancers（2023）

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摘要

Low detection of cHPV-DNA in early CC may be explained by small tumour size, poorer access to lymphatics and circulation, and therefore little shedding of cHPV-DNA in plasma at detectable levels. The detection rate of cHPV-DNA in patients with early invasive cervix cancer using even the most sensitive of currently available technologies lacks adequate sensitivity for clinical utility.

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关键词

human papillomavirus,cervical cancer,next generation sequencing,liquid biopsy,plasma,circulating DNA

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