Biomarkers of Response to Low-Dose Aspirin in Familial Adenomatous Polyposis Patients.

Angel Lanas,Stefania Tacconelli,Annalisa Contursi,Elena Piazuelo,Annalisa Bruno,Maurizio Ronci,Simone Marcone,Melania Dovizio,Federico Sopeña,Lorenza Falcone,Cristina Milillo,Matteo Mucci,Patrizia Ballerini,Paola Patrignani

Cancers（2023）

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摘要

Although low-dose Aspirin appropriately inhibited the platelet, persistently high systemic TXA and PGE biosynthesis were found, plausibly for a marginal inhibitory effect on prostanoid biosynthesis in the colorectum. Novel chemotherapeutic strategies in FAP can involve blocking the effects of TXA and PGE signaling with receptor antagonists.

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platelets, colorectal adenomas, cyclooxygenases, COX acetylation, thromboxane, prostaglandin E-2, familial adenomatous polyposis

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