An Isoxazoloquinone Derivative Inhibits Tumor Growth by Targeting STAT3 and Triggering Its Ubiquitin-Dependent Degradation.

Yuanzhu Xie, Shuaiwen Zhu,Ling Chen,Hongdou Liu,Ting Peng,Zhengnan Ming,Zizheng Zou,Xiyuan Hu,Wensong Luo,Kunjian Peng,Yuan Nie,Tiao Luo,Dayou Ma,Suyou Liu,Zhiyong Luo

Cancers（2023）

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摘要

We conclude that the novel isoxazoloquinone ZSW may be developed as a cancer therapeutic because it targets STAT3, thereby inhibiting the stemness of cancer cells.

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关键词

stat3,ubiquitin-dependent

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