Endoscopic ultrasound fine-needle biopsy to assess DAXX/ATRX expression and alternative lengthening of telomeres status in nonfunctional pancreatic neuroendocrine tumors

M. G. Mastrosimini,E. Manfrin,A. Remo,M. de Bellis,S. Pedron,C. Luchini,M. Brunelli,S. Ammendola,A. Pea,L. Landoni,A. Scarpa,S. F. Crino

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]（2023）

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摘要

Aims Death domain-associated protein (DAXX) and/or α-thalassemia/mental retardation X-linked (ATRX) genes mutations and alternative lengthening of telomeres (ALT) activation are associated with more aggressive behavior of non-functional pancreatic neuroendocrine tumors (NF-pNETs)[1] [2]. We aimed to evaluate their reliability on EUS-FNB specimens.

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关键词

Pancreatic cancer, Pancreatic tumor, ALT, FISH, Immunohistochemistry

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