Heterogeneity of Treatment Effects by Predicted Risk in Pulmonary Arterial Hypertension: An Individual Participant Data Meta-analysis

H. Pan,R. McClelland,J. Moutchia,D. Appleby,J. S. Fritz,J. Holmes,J. Minhas,H. I. Palevsky,R. Urbanowicz,S. M. Kawut, N. Al-Naamani

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE（2023）

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摘要

We found that predicted risk of one-year mortality in PAH modified treatment effect as measured by 6MWD, but not clinical worsening. Our findings highlight the importance of identifying sources of treatment heterogeneity by predicted risk to tailor studies to patients most likely to have the greatest treatment response.

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