ALKBH5 Drives Immune Suppression via targeting AXIN2 to Promote Colorectal Cancer and is a Target for Boosting Immunotherapy.

Jianning Zhai,Huarong Chen,Chi Chun Wong,Yao Peng,Hongyan Gou,Jingwan Zhang,Yasi Pan,Danyu Chen,Yufeng Lin,Shiyan Wang,Wei Kang,Ka Fai To,Zhiwei Chen,Yuqiang Nie,Housheng Hansen He,Joseph Jao-Yiu Sung,Jun Yu

Gastroenterology（2023）

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摘要

Our study identifies an ALKBH5-mA-AXIN2-Wnt-DKK1 axis in CRC which drives immune suppression to facilitate tumorigenesis. Targeting of ALKBH5 is a promising strategy for sensitizing CRC to immunotherapy.

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关键词

Colorectal Cancer,m6A Modification,Wnt/β-Catenin Signaling,DKK1,MDSCs

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