Novel fibro-inflammatory biomarkers associated with disease activity in patients with Crohn's disease.
Expert review of gastroenterology & hepatology(2023)
摘要
Current data suggest intestinal fibrosis may sustain and exacerbate chronic inflammation, leading to non-response to anti-inflammatory treatments. Therefore, evaluating novel biomarkers reflecting different stages of fibro-inflammatory disease activity should be done in a clinical setting and considered for clinical trials. This approach will help accurately assess disease activity, leading to better management and treatment of CD.
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关键词
Biomarkers, disease activity, Crohn's disease, protein fingerprint, proximity extension assay, aptamers, fibro-inflammation, serum calprotectin
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