Reparative, Neuroprotective and Anti-neurodegenerative Effects of Granulocyte Colony Stimulating Factor in Radiation-Induced Brain Injury Model.

Gökhan Gürkan,Özüm Atasoy,Nilsu Çini,İbrahim Halil Sever,Bahattin Özkul, Gökhan Yaprak,Cansın Şirin,Yiğit Uyanıkgil,Ceren Kızmazoğlu,Mümin Alper Erdoğan,Oytun Erbaş

Journal of Korean Neurosurgical Society（2023）

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摘要

In this first designed brain irradiation animal model, which evaluated G-CSF effects, we observed that G-CSF had reparative, neuroprotective and anti-neurodegenerative effects and had increased neurotrophic factor expression, neuronal counts, and morphology changes. In addition, G-CSF had a proven lactate-lowering effect in MR spectroscopy and brain materials.

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关键词

Animal models, Anxiolytic, Brain injuries, Irradiation, Granulocyte colony stimulating factor

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