Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.

Schizophrenia bulletin(2023)

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摘要
Based on these findings, we propose that pro-myelinating drugs (e.g., the histamine blocker clemastine) combined with aerobic exercise training may foster the regeneration of myelin plasticity as a basis for restoring frontotemporal connectivity and cognition in schizophrenia.
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关键词
oligodendrocytes, oligodendrocyte precursor cells, myelination, cognition, hippocampus, prefrontal cortex
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