Tracing the origins of midlife despair: association of psychopathology during adolescence with a syndrome of despair-related maladies at midlife.

Grace M Brennan,Terrie E Moffitt,Antony Ambler,HonaLee Harrington,Sean Hogan,Renate M Houts,Ramakrishnan Mani,Richie Poulton,Sandhya Ramrakha,Avshalom Caspi

Psychological medicine（2023）

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摘要

Midlife adults who exhibited a more severe syndrome of despair-related maladies tended to have had psychopathology as adolescents. Prevention and treatment of adolescent psychopathology may mitigate despair-related maladies at midlife and ultimately reduce deaths of despair.

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midlife despair,psychopathology,adolescence,despair-related

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