ACT-107, a novel variant of AmpC β-lactamase from Enterobacter huaxiensis isolated from Neotropical leaf frog (Phyllomedusa distincta) inhabiting the Brazilian Atlantic Forest

Johana Becerra,Gabriel G. Araujo,Felipe Vasquez-Ponce,Faride Lamadrid-Feris,Nilton Lincopan

Journal of Global Antimicrobial Resistance（2023）

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摘要

•In silico characterisation of a novel AmpC variant from E. huaxiensis is presented.•The variant confers resistance to broad-spectrum cephalosporins and cephamycins.•ACT-107 AmpC displays 12 unique mutations within the ACT family.•Frogs may represent important hosts of emerging species with novel β-lactamases.

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关键词

AmpC β-lactamase,Enterobacter Spp.,Antimicrobial resistance,Brazilian Atlantic Forest,Genomic surveillance

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