Irradiation is not sufficient to eradicate residual immortalized erythroid cells in in vitro-generated red blood cell products.

Suyeon Kim,Kyeong Won Jo,Ju Mi Park, Arim Shin,Ryo Kurita,Yukio Nakamura,Soonho Kweon,Eun Jung Baek

Transfusion（2023）

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摘要

Irradiation cannot induce total cell death of oncogene-expressing erythroblasts and leukocyte filter efficiency is not 100%. Therefore, our findings imply that for clinical applications, safer methods should be developed to completely remove residual nucleated cells from cell line-derived RBC products.

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关键词

erythrocytes, immortalization, in vitro RBC production, patient safety, radiation

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