Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis.

Xiaolei Wang,Jia Song,Yue Yuan,Luge Li,Issam Abu-Taha,Jordi Heijman,Liang Sun,Shokoufeh Dobrev,Markus Kamler,Liang Xie,Xander H T Wehrens,Frank T Horrigan,Dobromir Dobrev,Na Li

Circulation research（2023）

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摘要

This is the first study to demonstrate a role for the FKBP5-deficiency in atrial arrhythmogenesis and to establish FKBP5 as a negative regulator of hypoxia-inducible factor 1α in cardiomyocytes. Our results identify a potential molecular mechanism for the proarrhythmic NCX1 upregulation in chronic AF patients.

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animals, atrial fibrillation, electrophysiology, mice

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