The role of antifreeze glycoprotein (AFGP) and polyvinyl alcohol/polyglycerol (X/Z-1000) as ice modulators during partial freezing of rat livers.

Shannon N Tessier,Omar Haque,Casie A Pendexter,Stephanie E J Cronin,Ehab O A Hafiz,Lindong Weng,Heidi Yeh,James F Markmann,Michael J Taylor,Gregory M Fahy,Mehmet Toner,Korkut Uygun

Frontiers in physics（2022）

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摘要

Further research is necessary to optimize the ideal ice modulator cocktail for our partial-freezing protocol. Modifications to cryoprotective agent (CPA) combinations, including testing additional ice modulators, can help improve the viability of these partially frozen organs.

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关键词

antifreeze glycoprotein,polyvinyl alcohol,polyglycerol,cryopreservation,partial freezing,machine perfusion

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