Intestinal microbiomics and hepatic metabolomics insights into the potential mechanisms of probiotic Bifidobacterium pseudolongum CCFM1253 preventing acute liver injury in mice.

Weiling Guo,Shumao Cui,Xin Tang,Yongqiu Yan,Feifei Xiong,Qiuxiang Zhang,Jianxin Zhao,Bingyong Mao,Hao Zhang

Journal of the science of food and agriculture（2023）

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摘要

Bifidobacterium pseudolongum CCFM1253 can effectively alleviate inflammatory response and oxidative stress, and regulate the intestinal microbiota composition and liver metabolism, and elevate the liver riboflavin content in LPS-treated mice. Therefore, B. pseudolongum CCFM1253 could serves as a potential probiotic to ameliorate the host health. © 2023 Society of Chemical Industry.

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关键词

Bifidobacterium pseudolongum, acute liver injury, intestinal microbiota, liver metabolomics, riboflavin

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