Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression.

Veronica Finisguerra,Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck,Lionel Mignion,Bernard Gallez,Benoit J Van den Eynde

Journal for immunotherapy of cancer（2023）

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摘要

This study describes a novel mechanism of action of metformin and presents a promising strategy to achieve immune rejection in hypoxic and immunosuppressive tumors, which would otherwise be resistant to immunotherapy.

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关键词

cancer immunotherapy,metformin,immunosuppression,tumor-infiltrating,hypoxia-induced

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