Non-linear effects and effect modification at the participant-level in IPD meta-analysis part 1: Analysis methods are often substandard.

Nadine Marlin,Peter J Godolphin,Richard Hooper,Richard D Riley,Ewelina Rogozinska

Journal of clinical epidemiology（2023）

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摘要

Investigation of effect modification at the participant-level is common in IPDMA projects, but methods are often open to bias or lack detailed descriptions. Non-linearity of continuous covariates and power of IPDMA are rarely assessed.

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