Therapeutic Approaches of Dual-targeted Nanomedicines for Tumor Multi-drug Resistance

Weili Han, Zhenglin Shen, Jie Zou,Qiufang Ye, Cheng Ge,Yuqin Zhao,Ting Wang,Yafang Chen

Current drug delivery(2024)

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摘要
Currently, the main cause of cancer chemotherapy failure is multi-drug resistance (MDR), which involves a variety of complex mechanisms. Compared with traditional small-molecule chemotherapy, targeted nanomedicines offer promising alternative strategies as an emerging form of therapy, especially active targeted nanomedicines. However, although single-targeted nanomedicines have made some progress in tumor therapy, the complexity of tumor microenvironment and tumor heterogeneity limits their efficacy. Dual-targeted nanomedicines can simultaneously target two tumor-specific factors that cause tumor MDR, which have the potential in overcoming tumor MDR superior to single-targeted nanomedicines by further enhancing cell uptake and cytotoxicity in new forms, as well as the effectiveness of tumor-targeted delivery. This review discusses tumor MDR mechanisms and the latest achievements applied to dual-targeted nanomedicines in tumor MDR.
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关键词
nanomedicines,resistance,therapeutic approaches,dual-targeted
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