Spatial profiling of the microenvironment reveals low intratumoral heterogeneity and STK11-associated immune evasion in therapy-naïve lung adenocarcinomas.

Hannah Goldschmid,Klaus Kluck,Markus Ball,Martina Kirchner,Michael Allgäuer,Hauke Winter,Felix Herth,Claus-Peter Heußel,Soni Savai Pullamsetti,Rajkumar Savai,Timothy Tay Kwang Yong,Peter Schirmacher,Solange Peters,Michael Thomas,Petros Christopoulos,Jan Budczies,Albrecht Stenzinger,Daniel Kazdal

Lung cancer (Amsterdam, Netherlands)（2023）

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摘要

Early-stage lung adenocarcinomas show considerable intertumoral, but limited intratumoral heterogeneity, which is clinically highly relevant as assessment before neoadjuvant treatment is based on small biopsies. STK11 mutations are specifically associated with a 'cold' TME, which could affect the efficacy of perioperative immunotherapy.

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关键词

Intertumoral heterogeneity, Tumor microenvironment, STK11, Lung adenocarcinoma, TME

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