Analysis of Plasma Circulating Tumor DNA in Borderline Resectable Pancreatic Cancer Treated with Neoadjuvant Modified FOLFIRINOX: Clinical Relevance of DNA Damage Repair Gene Alteration Detection.

Dong-Hoon Lim,Hyunseok Yoon,Kyu-Pyo Kim,Baek-Yeol Ryoo,Sang Soo Lee,Do Hyun Park,Tae Jun Song,Dae Wook Hwang,Jae Hoon Lee,Ki Byung Song,Song Cheol Kim,Seung-Mo Hong,Jaewon Hyung,Changhoon Yoo

Cancer research and treatment（2023）

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摘要

Detection of DDR gene mutations from plasma ctDNA at baseline was associated with better survival outcomes of patients with borderline resectable PDAC treated with neoadjuvant mFOLFIRINOX and may be a prognostic biomarker.

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